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ComboSyn Inc compusyn for drug combinations
Compusyn For Drug Combinations, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compusyn+for+drug+combinations/compusyn+for+drug+combinations/pm39408931-581-2-34
Average 90 stars, based on 1 article reviews
compusyn for drug combinations - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Co-delivery of Docetaxel and Disulfonate Tetraphenyl Chlorin in One Nanoparticle Produces Strong Synergism between Chemo- and Photodynamic Therapy in Drug-Sensitive and -Resistant Cancer Cells.
Article Snippet: Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity and overcoming drug resistance, provided that optimized drug concentration ratios are delivered into the target tissue.. To these purposes, delivery systems such as nanoparticles (NPs), offer the unique opportunity to finely tune the drug loading and the release rate of drug combinations in the target tissues.. Here, we propose double-layered polymeric NPs for the delivery of the chemotherapeutic docetaxel (DTX) and the photosensitizer disulphonate tetraphenyl chlorin (TPCS2a) coated with hyaluronic acid (HA) which allows cell targeting via CD44 receptors.

Software:

Article Title: Chemical inhibitors of
Article Snippet: .. Chou, T. and N. Martin, CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values, in ComboSyn, Paramus, N J. ..

Article Title: Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme
Article Snippet: .. [6] Chou, T., and Martin, N. (2005) CompuSyn for drug combinations: PC software and user's guide: a computer program for quantitation of synergism and antagonism in drug combinations, and the determination of IC50 and ED50 and LD50 values, In ComboSyn, Paramus, NJ. ..

Article Title: Multifunctional Pt(iv) prodrug candidates featuring the carboplatin core and deferoxamine.
Article Snippet: The synergistic combination of the anticancer drug carboplatin and the iron chelator deferoxamine (DFO) served as a foundation for the development of novel multifunctional prodrugs.. Hence, five platinum(IV) complexes, featuring the equatorial coordination sphere of carboplatin, and one or two DFO units incorporated at axial positions, were synthesized and characterized using ESI-HRMS, multinuclear (H, C, N, Pt) NMR spectroscopy and elemental analysis.. Analytical studies demonstrated that the chelating properties of the DFO moiety were not compromised after coupling to the platinum(IV) core.

Article Title: Toxicological interactions of ibuprofen and triclosan on biological activity of activated sludge.
Article Snippet: The growing use of pharmaceutical and personal care products increases their concentrations in the wastewater entering treatment plants and their levels into biological reactors.. The most extended biological wastewater treatment is the activated sludge process.. The toxicity of ibuprofen and triclosan, individually and combined, was studied by tracking the biological activity of the activated sludge measuring oxygen uptake rate and the inhibition of the esterase activity.

Article Title: The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade.
Article Snippet: Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent hydrolysis by glutaminase (GLS).. However, this metabolic addiction can be lost in the tumour microenvironment, rendering GLS inhibitors ineffective in the clinic.. Here we show that glutamine-addicted breast cancer cells adapt to chronic glutamine starvation, or GLS inhibition, via AMPK-mediated upregulation of the serine synthesis pathway (SSP).

Article Title: Use of sanglifehrin macrocyclic analogues as anticancer compounds
Article Snippet: .. CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values, ComboSyn Inc, Paramus, (NJ), 2005) and is shown in FIG. 7. ..

Article Title: Anti-Herpetic Activity of Killer Peptide (KP): An In Vitro Study.
Article Snippet: .. ; Martin, N. CompuSyn for Drug Combinations: PC Software and User’s Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values; ComboSyn Inc.: Paramus, NJ, USA, 2005. ..

Quantitation Assay:

Article Title: Chemical inhibitors of
Article Snippet: .. Chou, T. and N. Martin, CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values, in ComboSyn, Paramus, N J. ..

Article Title: Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme
Article Snippet: .. [6] Chou, T., and Martin, N. (2005) CompuSyn for drug combinations: PC software and user's guide: a computer program for quantitation of synergism and antagonism in drug combinations, and the determination of IC50 and ED50 and LD50 values, In ComboSyn, Paramus, NJ. ..

Article Title: Toxicological interactions of ibuprofen and triclosan on biological activity of activated sludge.
Article Snippet: The growing use of pharmaceutical and personal care products increases their concentrations in the wastewater entering treatment plants and their levels into biological reactors.. The most extended biological wastewater treatment is the activated sludge process.. The toxicity of ibuprofen and triclosan, individually and combined, was studied by tracking the biological activity of the activated sludge measuring oxygen uptake rate and the inhibition of the esterase activity.

Article Title: The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade.
Article Snippet: Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent hydrolysis by glutaminase (GLS).. However, this metabolic addiction can be lost in the tumour microenvironment, rendering GLS inhibitors ineffective in the clinic.. Here we show that glutamine-addicted breast cancer cells adapt to chronic glutamine starvation, or GLS inhibition, via AMPK-mediated upregulation of the serine synthesis pathway (SSP).

Article Title: Use of sanglifehrin macrocyclic analogues as anticancer compounds
Article Snippet: .. CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values, ComboSyn Inc, Paramus, (NJ), 2005) and is shown in FIG. 7. ..

Article Title: Anti-Herpetic Activity of Killer Peptide (KP): An In Vitro Study.
Article Snippet: .. ; Martin, N. CompuSyn for Drug Combinations: PC Software and User’s Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values; ComboSyn Inc.: Paramus, NJ, USA, 2005. ..



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